Common Myeloid Progenitor Cell Line

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CMP:

Megakaryocytes:

In the presence of interleukin 11, the descendants of the CMP gives rise to megakaryoblasts, which are large basophilic cells with a bean-shaped nucleus.
Under the influence of thrombopoietin, the megakaryoblast matures to form the megakaryocyte (be aware that thrombopoietin is also referred to as THPO and megakaryocyte growth and development factor (MGDF), and c-Mpl ligand).
Megakaryoctes are large cells with multilobed, irregular nuclei.

The plasma membrane of mature cells invaginates to form demarcation membranes that fragment the cytoplasm.
The fragments are shed into the blood as platelets, aka, thrombocytes, which perform key hemostatic functions.

Erythrocyte:

Erythropoietin (EPO) initiates the erythroid series, which begins with formation of the proerythroblast and ends with the mature erythrocyte (aka, red blood cell).

Granulocytes:

Granulocyte-macrophage colony stimulating factor (GM-CSF) triggers formation of the myeloblast, which will give rise to 4 of the

5 white blood cell lines:

Eosinophils

Interleukin 5 triggers production of eosinophils
These white blood cells are characterized by multi-lobed nuclei and bright orange/red staining granules.

Basophils

Interleukin 3 triggers production of basophils, which, as their name implies, are highly basophilic.

(be aware that interleukin 3 has widespread influence over the other cell lines, too.)

Neutrophils

Presence of granulocyte – colony stimulating factor (G-CSF), myeloblasts become neutrophils.

Agranulocytes:

Monocyte

In the presence of monoblast – colony stimulating factor (M-CSF), the monoblast gives rise to the monocyte
This white blood cell has a bean-shaped nucleus, with visible chromatin, and blue-gray cytoplasm.
Outside of the red marrow, the monocyte differentiates:

In the connective tissues, it becomes a macrophage, which can phagocytose dozens of particles, even damaged red blood cells.
In the bone, the macrophage becomes an osteoclast, which resorbs bone tissue during growth and remodeling.